Focused Ultrasound and Alzheimers Disease a Systematic Review Apa Citation
Short-Term Efficacy of Transcranial Focused Ultrasound to the Hippocampus in Alzheimer's Disease: A Preliminary Study
by 1,2 , 3,* , 1,ii,* , 3 , three 
, 1 , 4 , 5 and 5
one
Department of Nuclear Medicine, Incheon St. Mary's Hospital, Higher of Medicine, The Catholic University of Korea, Seoul 21431, Korea
2
Department of Radiology, Incheon St. Mary's Infirmary, Higher of Medicine, The Catholic University of Korea, Seoul 21431, Korea
3
Department of Neurology, Incheon St. Mary's Hospital, College of Medicine, The Cosmic University of Korea, Seoul 21431, Korea
4
Department of Biomedical Engineering, The Urban center College of New York, New York, NY 10031, Us
5
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
*
Authors to whom correspondence should exist addressed.
Bookish Editors: Félix Javier Jiménez-Jiménez and Yoshihiro Noda
Received: 10 Dec 2021 / Revised: 27 Jan 2022 / Accustomed: 3 Feb 2022 / Published: 9 February 2022
Abstract
Preclinical studies have suggested that depression-intensity transcranial focused ultrasound (tFUS) may have therapeutic potential for Alzheimer'due south disease (Ad) by opening the blood–brain bulwark (BBB), reducing amyloid pathology, and improving cognition. This study investigated the effects of tFUS on BBB opening, regional cerebral metabolic charge per unit of glucose (rCMRglu), and cognitive function in AD patients. Viii patients with Ad received image-guided tFUS to the right hippocampus immediately after intravenous injection of microbubble ultrasound contrast agents. Patients completed magnetic resonance imaging (MRI), eighteenF-fluoro-ii-deoxyglucose positron emission tomography (PET), and cognitive assessments earlier and after the sonication. No testify of transient BBB opening was institute on T1 dynamic contrast-enhanced MRI. Still, firsthand think (p = 0.03) and recognition memory (p = 0.02) were significantly improved on the verbal learning test. PET image analysis demonstrated increased rCMRglu in the right hippocampus (p = 0.001). In improver, increases of hippocampal rCMRglu were correlated with improvement in recognition memory (Spearman's ρ = 0.77, p = 0.02). No adverse event was observed. Our results suggest that tFUS to the hippocampus of AD patients may better rCMRglu of the target expanse and retentiveness in the curt term, fifty-fifty without BBB opening. Further larger sham-controlled trials with loger follow-upward are warranted to evaluate the efficacy and prophylactic of tFUS in patients with AD. View Full-Text
► ▼ Show Figures
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted apply, distribution, and reproduction in any medium, provided the original work is properly cited
Share and Cite
MDPI and ACS Way
Jeong, H.; Song, I.-U.; Chung, Y.-A.; Park, J.-Due south.; Na, S.-H.; Im, J.J.; Bikson, Chiliad.; Lee, Due west.; Yoo, S.-S. Short-Term Efficacy of Transcranial Focused Ultrasound to the Hippocampus in Alzheimer's Disease: A Preliminary Report. J. Pers. Med. 2022, 12, 250. https://doi.org/10.3390/jpm12020250
AMA Mode
Jeong H, Song I-U, Chung Y-A, Park J-S, Na S-H, Im JJ, Bikson M, Lee W, Yoo S-S. Brusque-Term Efficacy of Transcranial Focused Ultrasound to the Hippocampus in Alzheimer's Disease: A Preliminary Written report. Periodical of Personalized Medicine. 2022; 12(2):250. https://doi.org/10.3390/jpm12020250
Chicago/Turabian Fashion
Jeong, Hyeonseok, In-Britain Song, Yong-An Chung, Jong-Sik Park, Seung-Hee Na, Jooyeon J. Im, Marom Bikson, Wonhye Lee, and Seung-Schik Yoo. 2022. "Short-Term Efficacy of Transcranial Focused Ultrasound to the Hippocampus in Alzheimer'southward Disease: A Preliminary Written report" Periodical of Personalized Medicine 12, no. two: 250. https://doi.org/10.3390/jpm12020250
Note that from the showtime upshot of 2016, MDPI journals employ commodity numbers instead of page numbers. See further details here.
Article Metrics
Article Access Statistics
For more information on the periodical statistics, click here.
Multiple requests from the same IP address are counted as one view.
Source: https://www.mdpi.com/2075-4426/12/2/250
0 Response to "Focused Ultrasound and Alzheimers Disease a Systematic Review Apa Citation"
Postar um comentário